Dermofix Cream (Generic)

Dermofix Cream (generic of sertaconazole nitrate 2%) is a topical antifungal medication in the imidazole class, specifically used to treat a range of superficial fungal skin infections. It is effective against dermatophytes and yeasts, including Trichophyton rubrum, T. mentagrophytes, Epidermophyton floccosum, Candida species, and Malassezia (pityriasis versicolor) MedicinesFAQ+1Almasis Skincare.

Mechanism of Action:
The active ingredient, sertaconazole, works by inhibiting the enzyme 14-α demethylase (a cytochrome P-450 enzyme), preventing the conversion of lanosterol to ergosterol—an essential component of fungal cell membranes. This disruption increases membrane permeability and leads to fungal cell death. It may also interfere with fungal respiration and cell morphology. MedicinesFAQ+1

Indications and Usage:
Dermofix is indicated for fungal infections of the skin such as:

• Athlete’s foot (tinea pedis), including interdigital infections

• Ringworm of the body (tinea corporis), groin (tinea cruris), beard (tinea barbae), and hands (tinea manuum)

• Candidiasis (skin yeast infections)

• Pityriasis versicolor (Malassezia infections)

• Seborrheic dermatitis (in some regions) Almasis SkincareMedica RCPRoshetaMedicinesFAQ

Dosage and Administration:
Clean and thoroughly dry the affected area, then apply a thin layer of the cream twice daily (morning and evening). Continue treatment for 2–4 weeks or as advised by a healthcare provider. Gardenia PharmacyMedicinesFAQAlmasis Skincare

Safety and Precautions:

• May cause mild local reactions such as redness, burning sensation, dryness, or contact dermatitis in rare cases. MedicinesFAQAlmasis Skincare

• Discontinue use if severe irritation or allergic reactions occur and consult a healthcare provider. MedicinesFAQAlmasis Skincare

• Should not be used in the eyes, mouth, or other mucous membranes—intended for external use only. MedicinesFAQ

• Use with caution during pregnancy or breastfeeding; systemic absorption is minimal, but apply only if benefits outweigh risks. Almasis SkincareFarmaco

Additional Notes:
Dermofix is recognized under brand names such as Dermofix, Ertaczo, and Zalain, and is manufactured by Ferrer Internacional, among others. It’s available in various regions including UAE, Kenya, Egypt, and India. ActovercoMedica RCPAlmasis SkincareGardenia PharmacyFarmaco