Ceritinib 150 mg

Ceritinib 150 mg, marketed under the brand name Zykadia, is a prescription medication used to treat ALK-positive metastatic non-small cell lung cancer (NSCLC). It is a targeted therapy that inhibits the activity of the anaplastic lymphoma kinase (ALK) protein, which contributes to the growth of cancer cells.

Uses of Ceritinib 150 mg

Ceritinib is indicated for the treatment of adult patients with metastatic NSCLC whose tumors are anaplastic lymphoma kinase (ALK)-positive, as detected by an FDA-approved test.

How It Works

Ceritinib is a tyrosine kinase inhibitor that blocks the activity of the ALK protein, leading to the inhibition of tumor cell growth and survival. This targeted action helps in controlling the progression of ALK-positive NSCLC.

• Recommended Dose: 450 mg orally once daily with food.

• Missed Dose: If a dose is missed, take it as soon as possible unless the next dose is due within 12 hours. Do not take two doses at the same time.

• Vomiting: If vomiting occurs after taking a dose, do not take an additional dose and continue with the next scheduled dose.

Common Side Effects:

• Gastrointestinal issues: nausea, vomiting, diarrhea, abdominal pain.

• Fatigue.

• Loss of appetite.

• Weight loss.

Serious Side Effects:

• Liver toxicity: elevated liver enzymes, jaundice.

• Interstitial lung disease/pneumonitis: symptoms include cough, difficulty breathing.

• QT interval prolongation: can lead to serious heart arrhythmias.

• Hyperglycemia: increased blood sugar levels.

• Pancreatitis: inflammation of the pancreas.

• Liver Function: Monitor liver enzymes regularly; dose adjustments may be necessary.

• Heart Health: Monitor for QT interval prolongation; avoid use in patients with congenital long QT syndrome.

• Blood Sugar Levels: Monitor glucose levels; manage hyperglycemia as needed.

• Pancreatic Function: Monitor pancreatic enzymes; withhold treatment in case of significant elevations.

• Pregnancy: Ceritinib can cause fetal harm; effective contraception is recommended during treatment.

1. Can Ceritinib be taken with food?

Yes, Ceritinib should be taken with food to enhance its absorption and reduce gastrointestinal side effects.

2. What should I do if I miss a dose?

If a dose is missed, take it as soon as possible unless the next dose is due within 12 hours. Do not take two doses at the same time.

3. Are there any dietary restrictions while taking Ceritinib?

Grapefruit and grapefruit juice should be avoided as they can increase the level of Ceritinib in the blood, leading to potential side effects

4. Is Ceritinib suitable for all patients with NSCLC?

Ceritinib is specifically indicated for patients with ALK-positive metastatic NSCLC. A test to detect ALK positivity is required before starting treatment.